4 – Pregnenolone Sulfate and Aging of Cognitive Functions: Behavioral, Neurochemical and Morphological Investigations. Hormones and Behavior 40, 215-217 (2001), Mayo M et al. Cerebral Pregnenolone correlated with cognitive performance and is improved with replacement in deficient older adults. Pregnenolone increases Acetylcholine in amygdla, cortex and hippocampus so the brain works better and clearer.
Neuroactive Steroid Levels in Patients with Generalized Anxiety Disorder. The Journal of Neuropsychiatry and Clinical Neurosciences 2001; 13:396-398. Semeniuk, T et al. Patients with Generalized Anxiety Disorder were found to have statistically lower levels of Pregnenolone.
Analysis of neurosteroid levels in attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 2001 Sep;4(3):259-64. Strous RD et al. Inverse correlation between clinical symptoms and levels of DHEA and Pregnenolone in young male subjects aged 7-15 years with DSM-IV criteria of ADHD.
Neurosteroids in the Hippocampus: Neuronal Plasticity and Memory Stress. Schumacher M 1997 Oct;2(1):65-78. There is accumulating evidence that some neurosteroids, in particular pregnenolone sulfate, have strong influences on learning and memory processes, most likely by regulating neurotransmission in the hippocampus.